Determination of pancreatic left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of pancreatic left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA9, RNU6-737P, and MIR362, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of pancreatic left/right asymmetry activity versus SPATA9 in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPATA9 →	-0.172	-0.651	<.001	.002	3	2
LSCC	RNU6-737P →	+0.275	+1.165	.001	.002	3	2
LSCC	MIR362 →	+0.420	+0.751	.002	<.001	3	2
UCEC	DACT1 →	-0.785	-1.028	<.001	<.001	3	2
LUAD	TRIM49C →	-0.052	-0.491	.001	.004	3	2
LUAD	TESC →	+1.514	+0.593	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035469 vs SPATA9 — LSCC

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