Determination of pancreatic left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Determination of pancreatic left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP6, LRRC39, and CHST5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP6 grouped by Determination of pancreatic left/right asymmetry-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SENP6 →	-0.569	-0.742	.001	.007	3	4
LUNG_NSCLC_LUSC	LRRC39 →	-0.663	-0.333	.005	.002	3	3
LUNG_SCLC	CHST5 →	-0.501	-1.011	.007	.005	3	3
LUNG_NSCLC_LUSC	FNBP1L →	-1.068	-0.391	.005	<.001	3	3
LUNG_NSCLC_LUSC	C1QTNF3 →	-1.580	-0.425	<.001	<.001	3	3
LUNG_NSCLC_LUSC	SH3GLB1 →	-1.398	-0.513	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP6 by Determination of pancreatic left/right asymmetry activity — LUNG_SCLC

Explore this box plot interactively →