Determination of pancreatic left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Determination of pancreatic left/right asymmetry pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSENEN, GGT2, and HFE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSENEN grouped by Determination of pancreatic left/right asymmetry-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PSENEN →	+0.151	+1.052	.005	.005	3	4
CNS	GGT2 →	+0.270	+1.039	.001	<.001	3	4
SKIN	HFE →	-0.192	-0.757	.001	.004	3	4
SKIN	EDN2 →	-0.194	-0.912	.005	<.001	3	4
OESOPHAGUS	SETD1A →	+0.164	+0.938	.006	.008	3	4
URINARY_TRACT	PARL →	+0.223	+1.435	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSENEN by Determination of pancreatic left/right asymmetry activity — PANCREAS

Explore this box plot interactively →