Vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the Vesicle cargo loading pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, NID2, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle cargo loading activity versus PRKG1 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKG1 →	+0.652	+0.050	.004	.006	3	8
OV	NID2 →	+0.640	+0.078	<.001	<.001	3	7
OV	RSU1 →	+0.353	+0.066	<.001	<.001	3	6
OV	SEC24D →	+0.355	+0.055	.002	<.001	3	6
OV	SERBP1 →	-0.340	-0.062	<.001	<.001	3	6
OV	SNX9 →	+0.446	+0.062	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035459 vs PRKG1 — OV

Explore this scatter interactively →