Vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the Vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP2, SLF2, and ZNF699, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB11FIP2 grouped by Vesicle cargo loading-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RAB11FIP2 →	-0.508	-0.481	<.001	.002	3	4
SKIN	SLF2 →	-0.713	-0.656	<.001	.004	3	4
SKIN	ZNF699 →	-0.730	-0.448	<.001	.007	3	4
LUNG_NSCLC_LUSC	MEIS3 →	-2.287	-0.294	.007	.002	1	6
BREAST	MKRN2 →	-0.678	-0.477	.003	.007	3	4
LARGE_INTESTINE	CAPRIN2 →	-1.175	-0.624	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB11FIP2 by Vesicle cargo loading activity — SKIN

Explore this box plot interactively →