Vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the Vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB3L1, RFLNB, and KBTBD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle cargo loading activity versus CREB3L1 in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CREB3L1 →	+2.112	+0.380	.001	<.001	3	4
LUNG_NSCLC_LUAD	RFLNB →	-1.378	-0.420	.001	.005	3	3
URINARY_TRACT	KBTBD7 →	+1.071	+0.271	.004	.008	2	4
URINARY_TRACT	MARS2 →	-0.676	-0.142	.006	.004	3	3
BREAST	ADIRF →	+3.628	+0.442	.003	.004	3	3
BREAST	PUS10 →	-0.630	-0.401	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035459 vs CREB3L1 — BREAST

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