Vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the Vesicle cargo loading pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPB1, COPB2, and COPA, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle cargo loading activity versus COPB1 in LIVER (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	COPB1 →	+1.024	+0.327	.008	<.001	3	14
LIVER	COPB2 →	+1.110	+0.375	.007	.001	3	14
BREAST	COPA →	+0.762	+0.367	<.001	<.001	3	13
PANCREAS	SEC23A →	+1.515	+0.432	<.001	<.001	3	12
BREAST	SEC31A →	+0.863	+0.418	.005	.004	3	12
PANCREAS	SEC24C →	+1.158	+0.354	.002	.003	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035459 vs COPB1 — LIVER

Explore this scatter interactively →