Cellular response to interferon-alpha

Across TCGA patient cohorts, RNA activity of the Cellular response to interferon-alpha pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, LMOD1, and MCM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-alpha activity versus SORBS1 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS1 →	+0.628	+0.062	<.001	<.001	3	8
BRCA	LMOD1 →	+0.695	+0.057	<.001	<.001	3	8
LUAD	MCM3 →	-0.652	-0.047	<.001	<.001	3	8
UCEC	PRKG1 →	+0.683	+0.078	<.001	.002	3	8
GBM	GAS6 →	+0.492	+0.092	<.001	<.001	3	8
COAD	RFC1_S368 →	-0.602	-0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035457 vs SORBS1 — BRCA

Explore this scatter interactively →