Cellular response to interferon-alpha

Across TCGA patient cohorts, RNA activity of the Cellular response to interferon-alpha pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB3, SFXN5, and EIF4BP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-alpha activity versus HSPB3 in LUAD (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HSPB3 →	-0.417	-0.097	.007	.009	3	3
PDAC	SFXN5 →	+0.192	+0.668	.003	.003	3	3
BRCA	EIF4BP1 →	+0.458	+0.305	.002	.009	3	3
LSCC	DGCR6 →	+0.274	+0.158	.008	.003	3	2
LSCC	CEACAMP2 →	-0.225	-0.147	.003	.006	3	2
LSCC	NECAP1P2 →	-0.364	-0.143	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035457 vs HSPB3 — LUAD

Explore this scatter interactively →