Cellular response to interferon-alpha

Across TCGA cell cohorts, RNA activity of the Cellular response to interferon-alpha pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, SP100, and OAS2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-alpha activity versus GAS6 in BONE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GAS6 →	+2.890	+0.141	<.001	<.001	3	13
SOFT_TISSUE	SP100 →	+2.134	+0.125	<.001	<.001	3	11
SOFT_TISSUE	OAS2 →	+2.476	+0.170	<.001	<.001	3	11
BREAST	NLRC5 →	+1.336	+0.138	.008	.003	3	11
LIVER	AXL →	+4.093	+0.190	.002	.007	3	11
LUNG_NSCLC_LUAD	PPP1R15A →	+1.049	+0.132	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035457 vs GAS6 — BONE

Explore this scatter interactively →