Cellular response to interferon-alpha

Across TCGA cell cohorts, RNA activity of the Cellular response to interferon-alpha pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE12, RPLP0, and DHX30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-alpha activity versus PDE12 in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDE12 →	+0.697	+0.319	<.001	<.001	3	7
STOMACH	RPLP0 →	+0.928	+0.333	.002	<.001	3	6
LUNG_SCLC	DHX30 →	+0.536	+0.175	.002	.004	2	7
LUNG_SCLC	RPL14 →	+0.726	+0.316	.005	<.001	3	6
LUNG_SCLC	RPL29 →	+0.941	+0.284	.001	<.001	3	6
URINARY_TRACT	POLR3G →	+3.175	+0.686	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035457 vs PDE12 — LUNG_SCLC

Explore this scatter interactively →