Response to interferon-alpha

Across TCGA patient cohorts, RNA activity of the Response to interferon-alpha pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1, TLN1, and TNS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-alpha activity versus TNS1 in CCRCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS1 →	+0.287	+0.044	<.001	<.001	3	9
LSCC	TLN1 →	+0.261	+0.055	<.001	<.001	3	8
BRCA	TNS2 →	+0.303	+0.039	<.001	.003	2	9
BRCA	SSC5D →	+0.660	+0.046	<.001	<.001	3	8
CCRCC	PRKG1 →	+0.524	+0.055	<.001	<.001	3	8
BRCA	DCN →	+0.955	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035455 vs TNS1 — CCRCC

Explore this scatter interactively →