Response to interferon-alpha

Across TCGA patient cohorts, RNA activity of the Response to interferon-alpha pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM4, SERPING1, and OAS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-alpha activity versus CMTM4 in UCEC (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CMTM4 →	-0.641	-0.166	.001	.001	3	5
GBM	SERPING1 →	+0.559	+0.072	.006	.007	3	5
OV	OAS3 →	+1.153	+0.121	<.001	.003	3	4
OV	OAS2 →	+1.356	+0.186	<.001	<.001	3	4
OV	IFIT3 →	+1.614	+0.198	<.001	<.001	3	4
BRCA	IFI6 →	+1.219	+0.120	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035455 vs CMTM4 — UCEC

Explore this scatter interactively →