Response to interferon-alpha

Across TCGA patient cohorts, RNA activity of the Response to interferon-alpha pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIOBP_S1796, TPR_T653, and ADAR_T601, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-alpha activity versus TRIOBP_S1796 in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRIOBP_S1796 →	+0.476	+0.729	<.001	<.001	2	6
LSCC	TPR_T653 →	+0.511	+0.151	<.001	<.001	3	5
PDAC	ADAR_T601 →	+1.343	+0.778	<.001	<.001	3	4
LSCC	ADAR_T603 →	+0.969	+0.235	<.001	<.001	3	4
HNSC	ISG15 →	+0.883	+0.174	<.001	.007	2	5
LSCC	SAMD4B_S271 →	+0.788	+0.174	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035455 vs TRIOBP_S1796 — PDAC

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