Response to interferon-alpha

Across TCGA cell cohorts, RNA activity of the Response to interferon-alpha pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS7, SEC22C, and PDE12, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-alpha activity versus BBS7 in URINARY_TRACT (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BBS7 →	+0.882	+0.657	.004	.002	3	10
BLOOD_Lymphoma	SEC22C →	+0.600	+0.257	.002	.004	3	6
LUNG_NSCLC_LUAD	PDE12 →	+0.660	+0.299	.004	<.001	3	6
URINARY_TRACT	ZNF330 →	+0.865	+0.607	.002	.004	3	5
UPPER_AERODIGESTIVE_TRACT	ANP32E →	+0.889	+0.266	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CNTLN →	+0.839	+0.320	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035455 vs BBS7 — URINARY_TRACT

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