Dipeptide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Dipeptide transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPO, PRAM1_S484, and MYEF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dipeptide transmembrane transport activity versus MPO in COAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MPO →	+0.880	+0.041	<.001	.004	3	5
OV	PRAM1_S484 →	+0.720	+0.087	.002	<.001	3	5
COAD	MYEF2 →	-0.593	-0.053	.001	<.001	3	5
COAD	S100A12 →	+1.177	+0.047	<.001	.005	3	5
COAD	S100A9 →	+1.410	+0.048	<.001	.006	3	5
COAD	AZU1 →	+0.850	+0.045	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035442 vs MPO — COAD

Explore this scatter interactively →