Dipeptide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Dipeptide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL21P40, GSTM3, and WFDC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dipeptide transmembrane transport activity versus RPL21P40 in LUAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL21P40 →	-0.410	-0.550	<.001	.001	3	4
GBM	GSTM3 →	+0.830	+0.700	<.001	.003	3	3
GBM	WFDC5 →	-0.254	-0.646	.004	.004	3	3
PDAC	S100A9 →	+1.571	+0.612	<.001	.001	3	3
PDAC	GPRC5B →	-0.527	-0.391	<.001	.005	3	3
PDAC	SCN4B →	-0.555	-0.412	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035442 vs RPL21P40 — LUAD

Explore this scatter interactively →