Dipeptide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Dipeptide transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC26A6_S752, SLC3A2, and SLC7A11_S26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dipeptide transmembrane transport activity versus SLC26A6_S752 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC26A6_S752 →	+0.838	+0.410	<.001	<.001	3	4
UCEC	SLC3A2 →	+0.577	+0.881	<.001	<.001	3	4
UCEC	SLC7A11_S26 →	+1.400	+1.445	<.001	<.001	3	4
BRCA	BNIP1 →	+0.368	+0.367	<.001	<.001	3	4
PDAC	GRAMD4 →	+0.353	+0.407	<.001	<.001	3	4
PDAC	NDUFB6 →	+0.355	+0.477	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035442 vs SLC26A6_S752 — BRCA

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