Maintenance of protein localization in endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, NCOA7_S89, and MRPS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in endoplasmic reticulum activity versus YME1L1 in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	YME1L1 →	-0.349	-0.047	<.001	<.001	3	8
LUAD	NCOA7_S89 →	+0.762	+0.050	<.001	.003	3	7
LSCC	MRPS2 →	-0.367	-0.045	<.001	.002	3	6
BRCA	MRPS5 →	-0.361	-0.045	<.001	<.001	3	6
CCRCC	FILIP1L →	+0.541	+0.055	.001	<.001	3	6
BRCA	MRPS18B →	-0.360	-0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035437 vs YME1L1 — BRCA

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