Maintenance of protein localization in endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C6P, TBC1D4, and ASXL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in endoplasmic reticulum activity versus AKR1C6P in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AKR1C6P →	-0.491	-0.212	.007	<.001	3	4
COAD	TBC1D4 →	-0.390	-0.095	.002	.003	3	4
COAD	ASXL1 →	-0.532	-0.128	.001	.002	3	4
CCRCC	QKI →	-0.277	-0.200	.008	.003	3	3
COAD	TGIF2 →	-0.394	-0.116	.005	<.001	3	3
CCRCC	KLF12 →	-0.306	-0.134	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035437 vs AKR1C6P — CCRCC

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