Maintenance of protein localization in endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RER1, STT3B_S498, and YIF1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in endoplasmic reticulum activity versus RER1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RER1 →	+0.421	+0.367	.001	.006	2	5
BRCA	STT3B_S498 →	+0.669	+0.506	<.001	<.001	3	4
UCEC	YIF1A →	+0.338	+0.167	<.001	<.001	3	4
CCRCC	GPAA1 →	+0.405	+0.224	<.001	.001	3	4
UCEC	PIGK →	+0.516	+0.199	<.001	<.001	3	4
UCEC	PIGS →	+0.412	+0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035437 vs RER1 — BRCA

Explore this scatter interactively →