Maintenance of protein localization in endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, CRACD, and NUDT14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA1 grouped by Maintenance of protein localization in endoplasmic reticulum-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABCA1 →	-2.123	-0.910	<.001	.005	3	5
CNS	CRACD →	+0.891	+0.833	<.001	.002	3	5
SOFT_TISSUE	NUDT14 →	+1.120	+0.915	.002	.005	3	4
PANCREAS	FUT8 →	-1.703	-1.428	.003	<.001	3	4
SKIN	BCHE →	+2.538	+1.009	.003	.001	2	5
SKIN	IL7R →	-2.079	-0.856	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA1 by Maintenance of protein localization in endoplasmic reticulum activity — SOFT_TISSUE

Explore this box plot interactively →