Maintenance of protein localization in endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC19A2, MS4A2, and CARD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC19A2 grouped by Maintenance of protein localization in endoplasmic reticulum-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC19A2 →	+0.173	+0.168	<.001	<.001	3	5
STOMACH	MS4A2 →	-0.274	-0.139	<.001	.001	3	5
OVARY	CARD10 →	+0.230	+0.092	.005	.001	3	4
OVARY	USP16 →	-0.113	-0.140	<.001	<.001	3	4
OVARY	PACSIN3 →	+0.183	+0.109	<.001	.008	3	4
OVARY	OR13A1 →	+0.139	+0.102	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC19A2 by Maintenance of protein localization in endoplasmic reticulum activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →