Maintenance of protein localization in endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Maintenance of protein localization in endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL7, OSBPL2, and SLC44A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein localization in endoplasmic reticulum activity versus ELOVL7 in BLOOD_Lymphoma (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ELOVL7 →	-2.084	-0.191	.005	.001	3	6
OVARY	OSBPL2 →	-0.911	-0.121	.006	.003	3	6
OVARY	SLC44A2 →	-2.059	-0.128	.002	.002	3	6
OVARY	GNB3 →	+1.057	+0.138	.002	<.001	3	6
LIVER	CTSD →	-2.054	-0.132	<.001	.003	3	5
OESOPHAGUS	RASAL2 →	-1.025	-0.086	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035437 vs ELOVL7 — BLOOD_Lymphoma

Explore this scatter interactively →