Phosphate ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Phosphate ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA6, STAP1, and FGF18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion transmembrane transport activity versus SPATA6 in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPATA6 →	-0.602	-0.571	.002	.001	3	4
HNSC	STAP1 →	-0.567	-0.225	<.001	.007	3	4
PDAC	FGF18 →	-0.578	-0.702	<.001	<.001	3	4
PDAC	BMPER →	-0.237	-0.517	.006	.004	3	4
HNSC	CDO1 →	-0.895	-0.216	<.001	.009	3	4
HNSC	SORBS1 →	-0.754	-0.419	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035435 vs SPATA6 — LSCC

Explore this scatter interactively →