Phosphate ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Phosphate ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QKI, ZC3H12A, and SYNC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, QKI grouped by Phosphate ion transmembrane transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	QKI →	-1.021	-1.453	.001	<.001	3	5
OVARY	ZC3H12A →	-1.051	-0.988	.002	<.001	3	5
CNS	SYNC →	-1.350	-0.669	.004	.004	3	5
OVARY	PLSCR4 →	-1.669	-1.018	.003	.003	3	5
LARGE_INTESTINE	VOPP1 →	-0.884	-1.095	.009	.001	3	5
LIVER	ABLIM3 →	-2.753	-1.551	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QKI by Phosphate ion transmembrane transport activity — URINARY_TRACT

Explore this box plot interactively →