Copper ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Copper ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAF2, RFC1_S368, and TERF2IP_S154, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion transmembrane transport activity versus TAF2 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TAF2 →	-0.339	-0.073	<.001	<.001	3	6
GBM	RFC1_S368 →	-0.736	-0.091	<.001	<.001	3	6
BRCA	TERF2IP_S154 →	-0.688	-0.063	<.001	<.001	3	6
BRCA	REPS2_S493 →	+0.906	+0.075	.007	<.001	3	6
BRCA	UTRN →	+0.383	+0.079	<.001	<.001	3	6
BRCA	KIF23 →	-0.464	-0.058	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035434 vs TAF2 — LSCC

Explore this scatter interactively →