Copper ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Copper ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, GAS1, and MYLIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCA grouped by Copper ion transmembrane transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FANCA →	+1.118	+0.892	.003	.001	3	5
SOFT_TISSUE	GAS1 →	+4.442	+1.146	<.001	.004	3	4
BONE	MYLIP →	+1.030	+1.483	.004	.007	3	4
LIVER	TMEM170A →	+0.839	+1.878	<.001	<.001	2	5
LUNG_NSCLC_LUAD	ATAD1 →	+0.633	+0.593	<.001	.005	3	4
LUNG_NSCLC_LUAD	TUBA8 →	+0.593	+0.807	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCA by Copper ion transmembrane transport activity — BREAST

Explore this box plot interactively →