Copper ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Copper ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, CDK7, and PITPNC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion transmembrane transport activity versus SGSM3 in BREAST (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SGSM3 →	+1.062	+1.142	.009	.005	3	3
BLOOD_Lymphoma	CDK7 →	-1.062	-1.668	.005	<.001	3	2
BLOOD_Lymphoma	PITPNC1 →	-1.770	-1.839	.007	.006	3	2
BLOOD_Lymphoma	MIER3 →	-0.803	-1.668	.008	<.001	3	2
BLOOD_Lymphoma	SVBP →	-0.465	-1.668	.003	<.001	3	2
BLOOD_Lymphoma	CHMP2B →	-0.718	-1.668	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035434 vs SGSM3 — BREAST

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