Extracellular matrix-cell signaling

Across TCGA patient cohorts, RNA activity of the Extracellular matrix-cell signaling pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41L5, NBEA, and TMC5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix-cell signaling activity versus EPB41L5 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EPB41L5 →	+0.623	+0.798	.001	.001	3	3
UCEC	NBEA →	+1.128	+0.774	<.001	.003	3	3
OV	TMC5 →	+1.158	+0.192	.005	.002	3	3
OV	RAP2C →	+0.657	+0.166	.009	.005	3	3
OV	PTPN13 →	+1.844	+0.195	.003	<.001	3	3
OV	LAMTOR3P2 →	+0.408	+0.122	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035426 vs EPB41L5 — UCEC

Explore this scatter interactively →