Autocrine signaling

Across TCGA patient cohorts, RNA activity of the Autocrine signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A12, ITGAM, and HNRNPR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autocrine signaling activity versus S100A12 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A12 →	+1.415	+0.082	<.001	<.001	3	8
PDAC	ITGAM →	+0.584	+0.090	<.001	<.001	3	8
GBM	HNRNPR →	-0.246	-0.085	<.001	<.001	3	8
GBM	MMP9 →	+0.962	+0.102	<.001	<.001	3	8
GBM	PADI4 →	+0.838	+0.088	<.001	<.001	3	8
GBM	PTX3 →	+0.910	+0.108	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035425 vs S100A12 — BRCA

Explore this scatter interactively →