Autocrine signaling

Across TCGA patient cohorts, RNA activity of the Autocrine signaling pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRG3, SAA2, and CEACAM3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autocrine signaling activity versus ADGRG3 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADGRG3 →	+1.075	+0.116	<.001	<.001	3	9
GBM	SAA2 →	+1.715	+0.252	<.001	<.001	3	8
COAD	CEACAM3 →	+0.653	+0.095	<.001	<.001	3	8
LUAD	VNN3 →	+0.687	+0.127	<.001	<.001	3	8
BRCA	S100A8 →	+2.712	+0.190	<.001	<.001	3	7
COAD	FCGR3B →	+1.314	+0.080	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035425 vs ADGRG3 — COAD

Explore this scatter interactively →