Autocrine signaling

Across TCGA cell cohorts, RNA activity of the Autocrine signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVI2B, SMIM34A, and CDKN3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autocrine signaling activity versus EVI2B in BREAST (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EVI2B →	+0.246	+2.688	<.001	.001	2	2
BREAST	SMIM34A →	+0.096	+2.688	.005	.001	2	2
BREAST	CDKN3 →	+1.250	+2.688	.001	.001	2	1
BREAST	KIAA0586 →	+0.960	+2.688	.002	.001	2	1
BREAST	PIEZO1 →	+1.008	+2.688	.003	.001	2	1
BREAST	CCP110 →	+0.835	+2.688	.009	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035425 vs EVI2B — BREAST

Explore this scatter interactively →