Protein localization to synapse

Across TCGA patient cohorts, RNA activity of the Protein localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CES1, MAP1A, and IQANK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to synapse activity versus CES1 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CES1 →	+2.108	+0.471	<.001	.005	3	5
UCEC	MAP1A →	+1.307	+0.838	<.001	<.001	3	5
UCEC	IQANK1 →	+0.941	+0.819	<.001	<.001	3	5
CCRCC	CTHRC1P1 →	-0.693	-0.322	<.001	<.001	3	4
UCEC	TMBIM1 →	+0.611	+0.561	.001	.001	3	4
LSCC	ACKR3 →	+1.063	+0.742	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035418 vs CES1 — LSCC

Explore this scatter interactively →