Protein localization to synapse

Across TCGA cell cohorts, RNA activity of the Protein localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FYCO1, TMEM94, and DSEL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to synapse activity versus FYCO1 in SKIN (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FYCO1 →	+1.179	+0.157	.003	.009	3	5
LUNG_NSCLC_LUAD	TMEM94 →	-0.769	-0.145	.003	.005	3	5
UPPER_AERODIGESTIVE_TRACT	DSEL →	+1.006	+0.244	.006	.001	3	5
BONE	CTC1 →	-1.081	-0.310	.001	.004	3	5
URINARY_TRACT	SACM1L →	+1.197	+0.347	.005	.002	3	4
SKIN	CCN3 →	+2.793	+0.174	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035418 vs FYCO1 — SKIN

Explore this scatter interactively →