Roundabout signaling pathway

Across TCGA patient cohorts, RNA activity of the Roundabout signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCOR3, LINC01943, and PLAU, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Roundabout signaling pathway activity versus RCOR3 in UCEC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCOR3 →	-0.458	-0.153	<.001	.005	3	5
COAD	LINC01943 →	+0.357	+0.369	.002	<.001	3	4
CCRCC	PLAU →	+0.676	+0.385	.005	.002	3	4
UCEC	ALDH6A1 →	-0.551	-0.148	.003	.007	3	4
COAD	CCL8 →	+1.386	+0.482	<.001	<.001	3	3
OV	LRRC4C →	+0.620	+0.396	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035385 vs RCOR3 — UCEC

Explore this scatter interactively →