Protein localization to microtubule

Across TCGA patient cohorts, RNA activity of the Protein localization to microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE3, MAP1A, and MAP1LC3A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to microtubule activity versus MAPRE3 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAPRE3 →	+0.513	+0.090	<.001	<.001	3	9
HNSC	MAP1A →	+0.531	+0.055	<.001	<.001	3	8
LSCC	MAP1LC3A →	+0.934	+0.079	<.001	<.001	3	7
HNSC	MAP1A_S2106 →	+0.787	+0.067	<.001	<.001	3	7
HNSC	MAP1A_S667 →	+0.740	+0.066	<.001	<.001	3	7
OV	MMP2 →	+0.745	+0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035372 vs MAPRE3 — HNSC

Explore this scatter interactively →