Protein localization to microtubule

Across TCGA cell cohorts, RNA activity of the Protein localization to microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM38, OGFR, and NELFCD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to microtubule activity versus RBM38 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBM38 →	+1.266	+0.164	<.001	.001	3	5
PANCREAS	OGFR →	+1.049	+0.179	.005	.001	3	5
CNS	NELFCD →	+0.653	+0.209	<.001	.001	3	4
CNS	MOCS3 →	+0.444	+0.179	<.001	.001	3	4
STOMACH	CTNNBL1 →	+1.107	+0.195	.004	.001	3	4
CNS	LSM14B →	+0.566	+0.189	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035372 vs RBM38 — BREAST

Explore this scatter interactively →