NAD transmembrane transport

Across TCGA patient cohorts, RNA activity of the NAD transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHNAK_S511, DNMBP, and TAX1BP1_S666, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NAD transmembrane transport activity versus AHNAK_S511 in OV (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AHNAK_S511 →	-0.566	-0.044	<.001	<.001	3	4
GBM	DNMBP →	-0.329	-0.072	.002	<.001	3	4
CCRCC	TAX1BP1_S666 →	+0.375	+0.059	.001	.001	3	3
CCRCC	VCP_S748 →	+0.273	+0.048	.002	.003	3	3
CCRCC	FLNA_S1630 →	-0.631	-0.060	.001	<.001	3	3
CCRCC	FLNB_S983 →	-0.894	-0.061	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035352 vs AHNAK_S511 — OV

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