NAD transmembrane transport

Across TCGA patient cohorts, RNA activity of the NAD transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLCCI1, COL1A1, and PHACTR2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NAD transmembrane transport activity versus GLCCI1 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GLCCI1 →	+0.771	+0.098	.007	.003	3	1
GBM	COL1A1 →	-1.508	-0.081	.003	.005	3	1
GBM	PHACTR2 →	-0.664	-0.118	<.001	<.001	3	1
GBM	LAMA4 →	-0.957	-0.147	<.001	<.001	3	1
GBM	OGG1 →	+0.337	+0.098	.002	.003	3	1
GBM	TCEANC2 →	+0.325	+0.101	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035352 vs GLCCI1 — GBM

Explore this scatter interactively →