NAD transmembrane transport

Across TCGA cell cohorts, RNA activity of the NAD transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2A, PALM3, and METTL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DIPK2A grouped by NAD transmembrane transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DIPK2A →	-1.662	-0.885	.003	.007	3	4
LARGE_INTESTINE	PALM3 →	+1.531	+1.332	<.001	.002	3	4
BLOOD_Leukemia	METTL4 →	-0.857	-1.340	.004	<.001	3	3
LARGE_INTESTINE	OARD1 →	-0.716	-1.440	.005	.001	3	3
BLOOD_Leukemia	TPM1 →	-1.342	-1.144	.004	.001	2	4
LUNG_SCLC	SLC29A3 →	-1.266	-1.092	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DIPK2A by NAD transmembrane transport activity — SOFT_TISSUE

Explore this box plot interactively →