Fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD36, GJA1, and TMEM107, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA metabolic process activity versus CD36 in CCRCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD36 →	-0.958	-0.144	.002	<.001	3	4
CCRCC	GJA1 →	-0.619	-0.102	.008	.009	3	4
CCRCC	TMEM107 →	-0.235	-0.130	.005	.002	3	4
CCRCC	SSTR2 →	-0.366	-0.111	.005	.006	3	4
COAD	PDE1A →	-0.628	-0.115	.003	.005	3	4
GBM	TUB →	-0.773	-0.114	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035337 vs CD36 — CCRCC

Explore this scatter interactively →