Fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARF, PLEKHM3, and SLC39A9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARF grouped by Fatty-acyl-CoA metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CARF →	-1.013	-1.349	.002	.002	3	4
LUNG_NSCLC_LUSC	PLEKHM3 →	-0.846	-1.561	.004	<.001	3	4
CNS	SLC39A9 →	-0.517	-0.927	.007	.005	3	4
LUNG_SCLC	FAM189B →	+0.803	+1.404	.007	<.001	3	4
LUNG_SCLC	OSGEP →	+0.722	+1.166	.002	<.001	3	4
OVARY	TNKS →	+0.571	+0.898	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARF by Fatty-acyl-CoA metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →