Fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTC4S, PAIP2B, and TUBA1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA metabolic process activity versus LTC4S in PANCREAS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LTC4S →	+0.731	+0.231	.004	.007	3	6
STOMACH	PAIP2B →	+1.154	+0.188	<.001	.004	3	6
URINARY_TRACT	TUBA1C →	-1.362	-0.434	.004	.002	2	6
UPPER_AERODIGESTIVE_TRACT	C12orf45 →	-1.289	-0.210	.004	.002	3	5
LUNG_NSCLC_LUSC	MACC1 →	+2.974	+0.167	.002	.003	3	5
URINARY_TRACT	FBXL4 →	+0.733	+0.332	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035337 vs LTC4S — PANCREAS

Explore this scatter interactively →