Long-chain fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL6, ELOVL7, and ACSL5, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA metabolic process activity versus ELOVL6 in CHOL (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	ELOVL6 →	+1.417	+0.058	.001	.002	1	26
PCPG	ELOVL7 →	+1.046	+0.027	<.001	<.001	3	20
ESCA	ACSL5 →	+2.456	+0.064	<.001	<.001	3	17
UCS	FAR2 →	+1.331	+0.053	<.001	<.001	3	16
KICH	THEM5 →	+1.194	+0.044	.006	.001	1	18
THYM	EVA1B →	-0.852	-0.027	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035336 vs ELOVL6 — CHOL

Explore this scatter interactively →