Long-chain fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, SH3D19, and HSPA4L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA metabolic process activity versus FKBP7 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FKBP7 →	-0.413	-0.045	.001	.001	3	7
PDAC	SH3D19 →	-0.258	-0.038	<.001	<.001	3	7
GBM	HSPA4L →	+0.307	+0.051	.001	<.001	3	6
COAD	TPM4 →	-0.447	-0.034	.005	.003	3	5
COAD	JAM3 →	-0.267	-0.025	.003	.002	3	5
COAD	LGALS1 →	-0.478	-0.024	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035336 vs FKBP7 — GBM

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