Long-chain fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGLC7, IGLV1-44, and IGLV3-27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA metabolic process activity versus IGLC7 in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGLC7 →	+2.025	+0.149	<.001	<.001	3	4
LUAD	IGLV1-44 →	+0.955	+0.127	.002	.001	3	4
BRCA	IGLV3-27 →	+1.572	+0.213	.003	.002	3	4
LSCC	RRBP1 →	+0.274	+0.104	.001	.002	3	3
LSCC	KRT19 →	+0.758	+0.137	.008	.001	3	3
LSCC	SNRPCP10 →	-0.333	-0.114	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035336 vs IGLC7 — OV

Explore this scatter interactively →