Long-chain fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAQR7, ACVRL1, and CCR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAQR7 grouped by Long-chain fatty-acyl-CoA metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PAQR7 →	+0.106	+0.207	.003	.003	3	3
PANCREAS	ACVRL1 →	-0.156	-0.241	.001	.001	3	3
LUNG_NSCLC_LUSC	CCR1 →	+0.300	+0.280	.002	.003	3	3
OVARY	CLIC3 →	-0.148	-0.313	<.001	.002	3	3
LUNG_NSCLC_LUSC	ANKRD26 →	+0.146	+0.367	.002	.007	3	2
OVARY	SLCO1B1 →	-0.252	-0.265	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAQR7 by Long-chain fatty-acyl-CoA metabolic process activity — OVARY

Explore this box plot interactively →