Long-chain fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, ENDOD1, and DCBLD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA metabolic process activity versus CLU in LUNG_NSCLC_LUSC (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CLU →	+5.590	+0.346	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ENDOD1 →	+2.225	+0.345	<.001	<.001	3	4
LUNG_NSCLC_LUSC	DCBLD1 →	+2.484	+0.333	.004	.001	3	4
BLOOD_Lymphoma	STXBP5 →	+1.240	+0.941	<.001	.001	3	4
PANCREAS	LCA5L →	+0.407	+0.235	.008	.006	3	4
BLOOD_Lymphoma	RASGEF1B →	-2.201	-0.964	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035336 vs CLU — LUNG_NSCLC_LUSC

Explore this scatter interactively →