Peptidyl-tyrosine dephosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-tyrosine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYPC, COX4I2, and KIF11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine dephosphorylation activity versus GYPC in UCEC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GYPC →	+0.526	+0.463	.004	.005	3	6
LSCC	COX4I2 →	+0.482	+0.547	.004	.007	3	5
GBM	KIF11 →	-0.761	-0.657	<.001	.001	3	5
OV	CEACAM4 →	+0.471	+0.923	.001	.002	3	5
OV	ASPA →	+0.443	+0.877	.005	.004	3	5
LUAD	ZWINT →	-0.637	-0.588	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035335 vs GYPC — UCEC

Explore this scatter interactively →